Higenamine is a substance found in a variety of fruits and vegetables.  Historically, it was used for its ability to assist with breathing, but found its way into the pre workout realm thanks to its fat burning and focus-enhancing attributes.

What is Higenamine?

Also known as Norcoclaurine HCl, Higenamine is a β-1 AND β-2-adrenergic agonist.  This means that it acts on the beta-1 and beta-2 adrenergic receptors in the body.  It exerts effects similar to that of synephrine or a much milder ephedrine-like effect, hence why we’re seeing it pop up more and more frequently in pre workouts hitting the market.

Found in Nature

Higenamine is found in a wide array of plant, with the highest concentrations found in fruits of the nelumbo nucifera plant.  It has also been found in Nandina domestica Thunberg, Argemone mexicana, Aconite Root, Coptis japonica, and Magnolia salicifolia to name a few.

What are the higenamine benefits?

Higenamine has gone through the wringer in terms of clinical trials and studies and has proven its usefulness across a multitude of platforms.  Starting with the most relevant to workout supplementation:

  1. Burns Fat


    When it comes to fat burning, higenamine behaves similarly to synephrine, but is shown to be much safer!

    Thanks to higenamine’s ability to act as a β-1-adrenergic agonist it shares the similar fat-burning capabilities that ephedrine and synephrine exhibit.  Activating these β-1 receptors leads to:

    • Stimulates lipolysis[1]
    • Increased calorie expenditure[1]
    • Increased blood pressure[2]
    • Increased heart rate[2,3]

    Not only is higenamine a great thermogenic agent, it’s also a great FAT-BURNER as well!

  2. Lung Capacity / “Expander”

    Prior to its inclusion in the pre workout market, higenamine was used for hundreds of years in Asian medicine to treat poor breathing symptoms. As a β-2 agonist, higenamine induces bronchial dilation and tracheal relaxation… meaning it will widen your breathing tubes and improve lung function.[4,5]

    This is great news for those of us that tend to get winded or have trouble catching our breath during intense cardio sessions.

  3. Heart Healthy

    We’ve already touched on higenamine’s ability to increase heart rate, but it has also shown to increase the force and rate of contraction of the heart muscle itself.[3]

    Why is this good?

    Well, higenamine ALSO acts as a vasodilator on your muscles and liver allowing MORE blood to flow to these areas when supplemented.[5]


While there is no clinical evidence to support an “optimal” dose, higenamine tends to be dosed around 20-30mg when taken 2-3 times/day.

As you can see, higenamine provides a host of benefits to individuals who choose to add it to their supplement pool, the only question left is…

What’s it doing in the Nitramine Pre Workout?


A Nitramine user’s worst nightmare! Don’t let this happen to you… click the image to see the best deal

Did you not read all of the great benefits higenamine poses that we just talked about?

Oh, you just skipped down the page to get to the bottom line…

WELL, with all of the bluster that surrounded DMAA (1,3-dimethylamylamine) and led to its banishment from nearly all pre workouts, the supplement industry needed a new “golden boy” to turbocharge their pre workouts that was both safe and “natural.”

Applying the benefits listed above to the conditions with which a pre workout would be used, first and foremost it induces lipolysis and kick starts fat-burning.  That mean fatty acids are released into the bloodstream and your body will utilize those for energy instead of having to ingest unnecessary carbs.

Secondly, higenamine’s vasodilation benefits work synergistically with another vasodilator in Nitramine (Agmatine Sulfate) leading to increased blood flow to the muscles. This generates increased pumps and a better supply of nutrients to the muscles allowing you to keep crushing those lifting sessions.

Finally, your cardio sessions will get a much needed boost thanks to higenamine’s ability to dilate your bronchial tubes.  Better breathing capabilities leads to decreased gasping/coughing, increased oxygen consumption, and thus, MORE endurance during your workouts.

Wrap Up

As you can see, higenamine is a safe, effective, and natural ingredient that you will definitely want in a pre workout.  Thankfully, Myokem included it in Nitramine in its High Energy Blend!

This is one of the key components that separates Nitramine from every other run of the mill pre workout.  You’ll notice increased body temperature, stamina, and energy during your intense workouts and will be wondering why you’ve never felt like this before with other pre workouts on the market.

Ready to see how higenamine with turbocharge your workout?  Grab a sample of Nitramine below and get ready to take your workouts to the next level!

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